One of the greatest challenges of renewable resources is unpredictable nature of these resources. Nevertheless use of fossil-renewable integrated hybrid system, which uses some renewable resources rather than a single source, for the supply of power, is the most affordable and the most reliable method. In this study by use of analytical programming approach and 2012 base year statistics, production system of Khorasan Regional Electricity CO. has been simulated and the maximum renewable electricity potential, entered into power generation system. Results show that among all of solar, wind, biomass, geothermal and hydro, only solar power have enough capacity and potential to be substituted with fossil power. The comprehensive system, which uses all renewable potential power capacity, causes 6.38 TWh reduction in fossil power, 4.28 million tons emission, 10-fold increase in spot-hourly price and 21% reduction in grid stability which shows necessity of using stabilizer and storage equipment in the hybrid integrated production system and Technical and financial support from the government to reduce the cost of solar equipment.